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Application areas

2009-11-13T07:45:00Z

MagSi-STA

2009-08-13T13:34:03Z

MagSi-STA beads are magnetic silica beads coated with Streptavidin.

The beads can be used in numerous biological and biochemical applications based on the very strong Streptavidin-Biotin bonding. Silica beads coated with Streptavidin can be used to isolate biotinylated proteins or other biotinylated molecules out of different media. It's easy to bind a biotinylated antibody to the MagSi-STA bead to isolate a specific target protein out of a cell lysate.

Would you like to learn more about the advantages of our products? Please have a look to our application notes here.

Clikck here for more information about optimizing the physical and biological properties of magnetic beads specifically suited for IVD assays.

MagSi-S-Tools

2009-08-24T14:20:47Z

MagSi-S-Tools are particles for research & developmental use. MagnaMedics has more than 10 different coatings available for further bio-conjugations. Most common surface modifications for kit and application developmentare available.

Genomic Applications

2010-05-30T11:24:09Z

In the past decades genomics has been developed and segregated to a) high throughput applications like blood and food diagnostics, b) very complex assays like for epigenetics analysis or c) highly reliable assays needed for forensics and of course d) highly economical applications.

All those different applications, interests and needs can not be matched with one single method nor with one single magnetic bead. High throughput applications supported by robotic liquid handling stations typically need magnetic beads with strong magnetic response whereas highly complex, manual DNA extraction applications needs magnetic beads with highest DNA capture, DNA selectivity and lowest unspecific binding.

For this purpose MagnaMedics has developed different types of magnetic beads specifically tailored to your needs. This paper should guide you through our MagSi magnetic particle portfolio specifically designed for the different DNA extraction methods and applications.

Download HERE the Selection Guide

Protein and Peptide Applications

2010-05-30T11:22:58Z

Isolation, separation and purification of proteins and peptides, as well as of other specific molecules, is commonly used in biotechnology research and production. New separation techniques, capable of treating dilute solutions or solutions containing only minute amounts of target molecules in the presence of vast amounts of accompanying compounds in both small and large-scale processes, even in the presence of particulate matter, are necessary.

A wide variety of techniques are used today involving a variety of chromatography, electrophoresis, ultrafiltration, precipitation and other procedures, whereof affinity chromatography being one of the most important techniques. However, these basic techniques have severe disadvantages over the use of magnetic nanoparticle solutions as provided by MagnaMedics Diagnostics with its patented product portfolio.

Download HERE the Selection Guide

MagSi-DNA

2009-08-24T14:18:33Z

For rapid isolation of DNA and for essential purification steps these kits can be used in the determination of gene-expression or polymorphisms in metabolic or genetic hereditory diseases. The application of beads for isolating of DNA from cells needs to wash-out bound DNA, which can be done by different principles.

Recent tests revealed that the Magsi-DNA beads can be used with buffers from other suppliers. Click here to see the full report.

Slection Guide Proteomics

2010-05-30T11:19:34Z

MagSi-proteomics beads are magnetic beads that are an ideal tool for the purification, concentration and desalting of peptides and protein digests. The surface of the beads has been modified with C4, C8 and C18 -alkyl groups that are typical for reversed phase applications.

The MagSi-WCX (weak cation exchange) magnetic beads have the typical ion exchange properties well known from classical chromatography. Protein and peptides are charged at the surface and will be adsorbed to magnetic beads under low salt condition. Under high salt conditions or by pH shift the target proteins/peptides are eluted (ion exchanged). Due to the different binding/elution mechanisms the MagSi-WCX beads are a powerful alternative to the MagSi proteomics beads.

The MagSi-WAX (weak anion exchange) magnetic beads are the “counter” beads to the MagSi WCX beads. Binding, washing and elution are also triggered by the protein/peptide total net charge. The MagSi-WAX beads are ideally suited when more acidic proteins/peptides are expected in the sample. However, our protocols given in the corresponding product sheet cover buffer systems for acidic, neutral and basic conditions.
MagSi-WCX beads are magnetic silica beads with a high magnetic content optimized for protein and peptide separation. Since the MagSi-WCX and MagSi-WAX act as counter-beads, MagnaMedics recommends to test both types of beads, to see which suits best in your individual application.

Download HERE the Selection Guide

MagSi-proteomics

2009-08-24T14:16:55Z

Would you like to learn more about the advantages of our products?

You need help with selecting the right product for your application?

Please have a look to our application notes here.

MagSi-proteinA/G

2009-08-24T13:41:45Z

MagSi-protein A and/or G beads can be used to detect or isolate target proteins by coupling the Fc domain of the IgG antibody for a target protein. The advantage of these beads compared to streptavidin beads is that the antibody does not need to be biotinylated. So they are ideal for protein isolation and proteomics.

Would you like to learn more about the advantages of our products? Please have a look to our application notes here.

MagCustom

2009-08-24T14:01:10Z

What if catalogue products do not meet your needs? Suppose you have the antibody to capture your specific cells or proteins; you have a read out system at hand to detect different fluorescent dyes at different wavelengths, but the fluorescent signal is under the detection limit. We can provide a customized, rapid solution for you: MagCustom.
Our tailor made magnetic and non magnetic beads are available in small scales and at reasonable prices. No matter if you have to couple one or two different fluorescent dyes, a specific peptide, protein, or antibody. MagnaMedics will find a solution to develop the product to your demand.

MagCustom toolbox. Quantum dots (green) or fluorescent dyes (red) and any other molecules (?) can be encapsulated next to the FerroFluids (black). On the surface different biomolecules like antibodies, proteins, streptavidin (STA), protein A or G and other
biological and non-biological molecules can be attached on demand.

Speed and versatility of the manufacturing process enable us to offer beside ready to use products tailor-made particles with a wide range of features and short development cycles. We are able to produce beads consisting of silica, polymers or gelatin in a size range of 100 nm up to 5 μm with various tool-up possibilities:
• Magnetic / Non-Magnetic
• Thermo sensitive - Thermo stable
• Hydrophilic / Hydrophobic
• Choice of various fluorescent dyes, binding groups and ligand attachments
• ...

MagCustom workflow
To guarantee you a high standard and reliability we build up a process for handling of customer requests. The diagram below (example of the coupling of a specific antibody to magnetic beads of a specific size) gives you an idea of our workflow and the steps involved.

Download here the MagCustom brochure. Please contact us if you would like to discuss the possibilities of our MagCustom products for your specific applications. You can also fill in our checklist with your specific bead requirements and we will contact you to discuss the possibilities.