MagnaFacts Newsletter

Here we present a pilot study using MagSi-S NH2 1.0 magnetic particles as generic particle for covalent attachment of any kind of lectin. The wheat germ agglutinin (WGA), has been used as lectin example.
It could be demonstrated that the MagSi-S NH2 beads provide an effective tool for any kind of lectin based glycoproteomics study.

MagnaMedics' one solution approach for PCR clean up ánd DeoxyDye terminator removal, enables researchers to make flexible use of one kit for many common applications performed in genomic research.

In this article MagnaMedics Diagnostics B.V. will outline the use of MagSi products for biomarker discovery with emphasis on latest proteomics approaches known today.
◦ chemical proteomics research
◦ nuclear receptor research
◦ signal transduction pathway analysis research

MagnaMedics Diagnostics B.V. has developed a high magnetic content bead type with a size of 1.2 μm and 1.0 μm. The use of a new developed novel ferro fluid (Mag-Ferro) with an magnetisation of up to 40 emu/g allows MagnaMedics to upgrade the catalogue products. Raising the magnetic content from formally 30 – 40% to 40% - 55% enhances the time to magnet significantly.

Protein A and protein G are recombinant proteins that bind with high affinity to the Fc portion of several classes and subclasses of immunoglobulin (IgG´s) from a variety of species. Specific antigens are bound in a second step reversible towards the bound IgG. A following washing step and elution by pH shift generates the purified target protein under native conditions. MagSi protein A and G beads can be regenerated and reused several times (up to 10 times), incl large volume scales.

MagnaMedics presented it's MagnaFy Imaging Technology, that enables MRI-visualization of medical devices, at the 17th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (http://www.ismrm.org) held from April 18 – 24 in Hawaii, USA.

Magnetic reversed phase beads for clinical proteomics and biomarker validation

Working with biomarkers? Need methods to improve your analysis and/or separation. MagnaMedics can provide you with several tools to optimize your biomarker research. In this newsletter we highlight these products and inform you about the ongoing development of our new MagSi-phospho beads.

This newsletter is to keep our customers and clients up-to-date of the progress in product and application development with MagnaMedics. In this issue we want to 1) give you an update about our current product development and 2) highlight the potential to request special – customized – products that can be optimized to your specific needs. Here we give some examples of what can be possible by applying our know how to your needs.