Alterations in protein glycosylation occur during development and progression of many diseases including cancer, inflammation and autoimmune disease. Glycomics and glycoproteomics have emerged as important tools in glycobiomarker discovery. The most prominent lectin for capture of glycosylated proteins is Concanavalin A (Con A). However, in total there exist a pool of apr. 20 different lectins with individual selectivity towards glycosylated structures, complementing each other. Therefore it is necessary for a representative glycoproteomics study, to include not a single (e.g. ConA) but multiple lectins for glycoprotein pullout. Here we present a pilot study using MagSi-S NH2 1.0 magnetic particles as generic particle for covalent attachment of any kind of lectin.

MagnaMedics' one solution approach for PCR clean up ánd DeoxyDye terminator removal, enables researchers to make flexible use of one kit for many common applications performed in genomic research.

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